Unlike burnout, which is caused by everyday work stresses (dealing with insurance companies, making treatment choices), compassion fatigue results from taking on the emotional burden of a patient's agony.
In a way, it's similar to post-traumatic stress disorder, except that the stress is a reaction to the trauma of another. As with PTSD, symptoms include irritability, disturbed sleep, outbursts of anger, intrusive thoughts, and a desire to avoid anything having to do with the patient's struggle.
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